Beyond the famous Golden Gate Bridge and iconic streets, San Francisco is famous for being home to some of the biggest companies in the world.
The city’s tech scene is thriving, but companies in other industries also play a significant role in its economy.
These giants are generating billions in revenue and have the highest market caps in their sectors.
This article explores the leading companies in San Francisco and the impressive financial figures they’re recording.
To spotlight the most influential corporations in San Francisco, we considered factors such as market capitalization, annual revenue and industry impact (including job creation and technological innovation).
This overview aims to reflect a balance of both well-established giants and rising stars that embody San Francisco’s spirit of ambition and transformation.
Tech Companies In San Francisco
San Francisco is the epicenter of the tech industry in the U.S., with some of the biggest names in software, cybersecurity and cloud computing calling the city their home.
Among them is one of the four Fortune 500 companies headquartered in San Francisco — Salesforce. Together with Autodesk and Cloudflare, this famous cloud-based software company is at the forefront of the industry.
Their recent figures highlight their significant impact on the sector:
- Salesforce reported a total revenue of $34.86 billion in 2024.
- In 2024, Salesforce reported a net income of $4.13 billion.
- As of mid-March 2025, Salesforce has the highest market cap out of all San Francisco tech companies, at around $268 billion.
- In 2024, Salesforce had over 72,000 employees globally.
- The software corporation, Autodesk, reported a revenue of $5.49 billion in 2024.
- Autodesk has a market cap of around $57 billion as of mid-March 2025.
- $2.43 billion of Autodesk’s revenue in 2024 came from the U.S.
- Autodesk’s total assets amounted to $9.91 billion in 2024.
- Over 14,100 people are employed by Autodesk.
- Cloudflare reported a revenue of $1.66 billion in 2024.
- As of mid-March 2025, Cloudflare has a market cap of around $40 billion.
- Over 4,200 people are employed by Cloudflare.
- Samsara reported a revenue of $937.4 million in 2024.
- Samsara has a market cap of around $22 billion as of mid-March 2025.
Salesforce isn’t only the biggest tech company in the city in terms of market cap, but as of mid-March 2025, it’s also the second-biggest company overall in San Francisco. Its consistent ranking among the most valuable businesses in the U.S. reflects the enduring strength of cloud-driven solutions in today’s marketplace.
Meanwhile, the rise of AI-focused ventures in generative technology, automation tools and enterprise software signals a new frontier of innovation, one that could see these emerging startups rapidly scaling, further reinforcing San Francisco’s status as a global tech epicenter.
Finance Companies In San Francisco
San Francisco is the seat of the Pacific Stock Exchange and hosts some of the biggest banks and other financial services companies, including Visa and Wells Fargo.
The city also ranks among the biggest investment banking centers in the U.S.
Recent data about San Francisco finance companies shows their dominance in the market:
- Visa reported a revenue of $35.92 billion in 2024.
- As of mid-March 2025, Visa has a market cap of around $655 billion.
- Visa’s global brand value is $188.93 billion.
- Over 31,000 people are employed by Visa.
- Wells Fargo, one of the “Big Four Banks” in the U.S., reported a revenue of $82.29 billion in 2024.
- As of mid-March 2025, Wells Fargo has a market cap of around $236 billion.
- Wells Fargo employs around 217,000 people.
- Affirm Holdings reported a revenue of $2.3 billion in 2024.
- As of mid-March 2025, Affirm Holdings has a market cap of around $15 billion.
- Affirm Holdings reported 18.6 million active consumers in 2024.
Visa currently leads the finance sector with the city’s highest market cap, cementing San Francisco’s reputation as a global hub for payment processing and financial innovation.
Alongside legacy institutions like Wells Fargo, a growing number of fintech disruptors, such as Affirm Holdings, are rewriting how consumers and businesses handle transactions.
San Francisco’s unique blend of traditional banking powerhouses and agile fintech innovators ensures the city remains central to the evolution of modern finance.
Ride-Hailing Companies In San Francisco
Two of the biggest ride-hailing companies in the U.S., Uber and Lyft, are headquartered in San Francisco. They enable users to get a ride anywhere, at any time.
After experiencing success in the personal transportation sector, both companies expanded their services to include food delivery, bike and scooter rentals and more.
Their presence in San Francisco reflects the city’s role as a hub for technological innovation and the gig economy.
Let’s take a closer look at how these two companies have been performing lately:
- Uber, the ride-hailing and delivery giant, reported a total revenue of $43.97 billion in fiscal year 2024.
- In 2024, Uber generated $25.08 billion from its mobility segment.
- As of mid-March 2025, Uber has a market cap of around $156 billion.
- Lyft reported a revenue of $5.8 billion in 2024.
- In 2024, Lyft had a net income of $22.8 million.
- Lyft’s market cap stands at around $5 billion as of mid-March 2025.
Uber and Lyft have revolutionized personal mobility by enabling on-demand transportation and spearheading the gig economy.
As these ride-hailing giants extend into food delivery and bike or scooter rentals, they illustrate San Francisco’s capacity for continuous service innovation.
With autonomous vehicles moving from testing phases to real-world implementation, the city serves as a testing ground for next-generation mobility solutions.
Companies like Zoox, which was recently acquired by Amazon, are preparing for wider rollouts.
Healthcare Companies In San Francisco
With the tech industry leading the way in San Francisco, it’s no surprise its biggest healthcare companies are digital-first.
These businesses leverage technology to enhance patient care and medical communication, contributing to the modernization of healthcare services.
Below, we look at how healthcare companies in San Francisco are performing:
- The biggest healthcare company in San Francisco in terms of revenue is Hims & Hers Health with $1.48 billion in 2024.
- Hims & Hers Health had a net income of $126 million in 2024.
- Hims & Hers Health has a market cap of around $7 billion as of mid-March 2025.
- In 2024, the number of Hims & Hers Health subscribers reached 2.2 million.
- Doximity, the biggest online community of healthcare professionals in the U.S., reported a revenue of $475.4 million in 2024.
- In 2024, Doximity had a net income of $40.6 million.
- Doximity’s market cap stands at around $12 billion as of mid-March 2025.
- Over 80% of doctors and 50% of all NPs and physician assistants in the U.S. use Doximity.
San Francisco’s healthcare sector is increasingly intertwined with technological innovation, with companies like Hims & Hers Health and Doximity leading a shift toward digital-first care models.
Hims & Hers completely changed the way consumers access treatment for everyday health needs while Doximity became one of the most-used tools for medical professionals, allowing for easier communication, referrals and career development.
These companies are simplifying patient access to everyday treatments and streamlining communication among professionals, showcasing the power of technology in healthcare transformation.
As telemedicine, health apps and AI-driven diagnostics continue to grow, more startups and established companies in the Bay Area are expected to lead innovations that enhance global patient outcomes.
Real Estate Companies In San Francisco
San Francisco’s real estate sector is adapting to a shifting demand environment.
While residential housing remains competitive and limited, industrial and logistics properties have become increasingly valuable.
Companies like Prologis and Terreno Realty specialize in industrial real estate, reflecting this demand and signaling a pivot away from traditional office development.
- The real estate investment trust, Prologis, reported a revenue of $8.2 billion in 2024.
- Prologis had consolidated net earnings of $3.94 billion in 2024.
- With a market cap of around $104 billion as of mid-March 2025, Prologis is the biggest real estate company in San Francisco.
- Around 2,700 people are employed by Prologis.
- Terreno Realty reported a revenue of $382 million in 2024.
- In 2024, Terreno Realty had a net income of $184 million.
- As of mid-March 2025, Terreno Realty has a market cap of around $6 billion.
Due to eCommerce growth and the need for efficient supply chains, companies are establishing distribution centers closer to urban areas.
With limited residential space and changing office demands, San Francisco is increasingly focusing on warehouses and distribution centers.
This trend towards logistics-oriented real estate is part of a larger movement in the Bay Area, where adaptability is essential for maintaining long-term growth.
San Francisco-Based Companies In Other Industries
Besides the industries we listed earlier in this article, there are companies operating in other sectors that have made a significant impact.
From the online marketplace for homestays Airbnb and meal delivery giant DoorDash to social media platform Pinterest and community-driven Reddit, these companies have built strong brands and loyal user bases.
Below, we look at their recent financial performances:
- In 2024, Airbnb had revenue of $11.1 billion.
- Airbnb reported a net income of $2.64 billion in 2024.
- As of mid-March 2025, Airbnb has a market cap of around $78 billion.
- In 2024, Airbnb had $20.96 billion in total assets.
- 41%, the EMEA (Europe, Middle East and Africa) accounted for 41% of all Airbnb bookings while North America accounted for 31%.
- In the U.S., Airbnb has the most listings in Los Angeles, at 46,641.
- DoorDash reported a revenue of $10.72 billion in 2024.
- DoorDash had a net income of $123 million in 2024.
- As of mid-March 2025, DoorDash has a market cap of around $81 billion.
- 2.58 billion DoorDash orders were made in 2024.
- DoorDash has the highest market share of all meal delivery companies in the U.S. at 67%.
- Pinterest, one of the world’s biggest social media services, reported a revenue of $3.64 billion in 2024.
- In 2024, Pinterest had a net income of $1.86 billion.
- Pinterest has a market cap of around $21 billion as of mid-March 2025.
- 553 million people use Pinterest.
- 4,666 people are employed by Pinterest full-time.
- Reddit, the popular forum social network, had revenue of $1.3 billion in 2024.
- In 2024, Reddit reported a net loss of $484.3 million.
- As of mid-March 2025, Reddit has a market cap of around $20 billion.
- 2,233 people are employed by Reddit full-time. However, around 60,000 more volunteer moderators are active on the platform.
Airbnb, DoorDash, Pinterest and Reddit demonstrate the broader creative and technological reach of San Francisco’s business ecosystem.
These platforms have transformed travel, dining, and social media, showcasing the city’s ability to challenge established norms.
From short-term rentals to food delivery and online communities, these consumer-driven innovations keep growing in the Bay Area, boosting the economy and expanding globally.
Grow Your San Francisco Brand Online With Digital Silk
Recent performances of companies in San Francisco show just how competitive the city’s business environment is. As leaders in their respective industries, these companies must ensure every aspect of their business is running at peak performance.
One area that plays a major role in long-term success is a company’s digital presence.
That’s where Digital Silk comes in. As a San Francisco web design agency, our mission is to help you break through the noise.
From creating custom websites to developing strategic branding and performance-driven marketing campaigns, we tailor each solution to your unique goals — ensuring you stand out in a fiercely competitive market.
Other service we offer include:
Contact us online, call (800) 206-9413 or fill out the Request a Quote form below to schedule your free consultation.
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